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myshkin

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About myshkin

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  1. Can't really bring myself to watch the cycling anymore but I flicked over between races at Yarmouth and Lingfield yesterday and caught a bit of that freaky weirdo Froome (only a few minutes mind). That was enough for me. I would like to think he will be caught sooner rather than later but it's impossible to have any faith in the testing procedures so are probably looking at years down the line before they catch up.
  2. Richard Moore and David Walsh more than likely.
  3. If Sky had any sense they would make Henao the team leader now rather than anchor him on that miserable p***ks front wheel. The last time a knight of the realm worked for someone from the 3rd world would have been Mark Thatcher on one of his ill fated military ventures so it's not going to happen. Brailsford must be raging that he sacked paracetamol distributor Gert Leinders. What a dreadful mistake. At least they still have their comfy pillows. The Shark looks pretty strong with Tiralongo, Kessiakoff, Kangert and Agnoli all defending now that it goes uphill. Cadel looks a bit isolated unfortunately but good to see him back. Dupont and Pozzovivo to win stages and keep up their good start to the season.
  4. True, it was almost as if Clasicomano Luigi was still a client of Fuentes. Marvellous stuff, for my bank balance at least. Roll on Paris Roubaix so we can do it all again. And god bless the new generation (sic) like Porte, Sagan, Froome, Cancellara. It's like betting on US horse racing with lasix, only it's more accurate.
  5. I thought Wiggins comments about him were ill advised. Talk about putting a target on your back.
  6. I must say I quite enjoyed the first part of the show. It was never going to be the most forensic examination but Oprah Winfrey had obviously done a bit of swotting up and asked some pertinent questions. Obviously he was still pretty evasive on a lot of issues, sticking to the omerta and dodging the issue of the corruption in the UCI but the show was a worthwhile exercise purely to hear his yes/no answers right at the start of the interview. Watching him cringe and squirm at some of the recorded sections was an eye opener as well. Edit (I'm too boring to stay up till all hours so will be watching the 2nd part tonight so I don't want to know what happened at the end!)
  7. I didn't say I was surprised. Indeed, having seen all the early season races the performance of team Sky was exactly what I was expecting. The only surprise was that Michael Rodgers didn't do better in the time trials........... A performance spike to me is when a rider that has won nothing significant in the first eight or nine years of his career wins everything after shedding a fifth of his body weight and his team employ Gert Leinders.
  8. I've just finished reading David Walsh's Seven deadly sins. Highly reccomend it. Among many interesting things was a quote from Christophe Bassons: 'The spotlight now should not be on Lance Armstrong but on a sport that is still gangrenous with doping and deceit. The Tour de France 2012 did not reassure me'. He couldn't possibly be referring to the huge performance spike but one rider in particular could he? Shurely not..................
  9. Very sad. Bassons is on a Radio 5 special 7pm Monday evening along with others. Should be informative.
  10. Taraa!!!!! http://www.velonation.com/News/ID/11395/Doping-AICAR-Telmisartan-and-the-need-for-vigilance.aspx Doping: AICAR, Telmisartan and the need for vigilance by José Been at 3:39 PM EST Are weight loss, blood vessel-dilating products being used in the peloton? Following a warning by German anti-doping specialist Mario Thevis that up to 100 variants of EPO may exist without a current test, De Telegraaf today writes that the substance AICAR has been in use in the peloton for some time. It quotes several unnamed sources as saying that it is being utilised by riders who wish to benefit from its ability to decrease body weight while also dilating blood vessels. UCI President Pat McQuaid has acknowledged to the newspaper that AICAR use is currently difficult to prove, but that WADA is aware of it and efforts are being made to perfect a test. The substance first made the news in 2009 when the-then AFLD director Pierre Bordry said that he believed it was in use and that some riders were looking unnaturally thin to him. One of the most important determinants of success in cycling is power to weight, particularly in the mountains, and so any substance which can help riders lose body fat has advantages. Research relating to this first surfaced back in 2008, when Professor Ron Evans of La Jolla, California was doing research to find a cure for the increasing epidemic of obesity and diabetes. He found a substance that would trick the cells in thinking they exercised a lot while in fact they had been mostly idle. The mice ran faster, had better endurance and burnt fat. When the mice were actually following a training regime the results almost doubled. The media dubbed it the “coach-potato drug”, the miracle cure to obesity and diabetes for people who were unable to exercise. AICAR: The words AICAR and GW1516, the substances tested by Evans, buzzed around body building and fitness messageboards. By training and taking the drug, the suggestion was that you could increase your output. If athlete A was training without addition of the drugs and athlete B took the drugs next to training, the latter would have more strength and endurance with the same time investment in training. Or at least, that was the theory, since the tests by Evans were performed only in mice and no proper study has been done in humans. This is also acknowledged by Herman Ram of the Dutch Anti-Doping Authority. “People have been talking about AICAR for 15 years but effects have only been measured in animal studies,” he told this writer. “That means that there are unknown side effects possible when used in healthy human subjects.” Professor Evans realized too that this could be an ideal drug for endurance sports, like cycling, also because it burns fat, and informed WADA about it. The World Doping Authorization included it into their Prohibited List. That wasn’t the end of the matter. In 2009, after the Tour de France, the French anti-doping organization AFLD searched bins and reportedly found remnants of drugs that were “unlicensed”: third generation EPO, also known as Hematide, and AICAR. “These are products that shouldn’t be found around people who are supposed to be in good health,” AFLD scientific adviser Michel Rieu said then. The AFLD wanted to run more tests on the 2009 urine samples from the Tour but UCI held these samples and, according to Le Monde on July 28th, didn’t grant permission for re-analysis. Unfortunately for WADA, there are problems. Testing for AICAR is very tricky. It requires equipment that only advanced research labs have. Moreover, AICAR is a substance which closely resembles a protein that is naturally present in the body, as is the case for example for testosterone or EPO. Every substance entering a human body passes through the liver, resulting in so-called metabolites and these can be found in urine. The level of that protein’s traces in a person’s urine is very variable and depends on gender, level of activity, type of exercise and more. It is therefore difficult to determine a level that is normal and use that as a reference value. In other words, for synthetic substances like clenbuterol which don’t have a natural counterpart, the threshold would be zero since the body simply does not produce it itself. For AICAR, this threshold would be variable, complicating things. GW1516 ultimately never reached the market because clinical trials stopped in Phase II, for reasons unknown. It is only available to biomedical research labs. AICAR is a substance which is still in the testing phase for several applications but can be bought online. Positive turns negative: From an anti-doping point of view, there is one positive thing about AICAR: it’s very expensive to buy. The experiments Professor Evans ran involved a dose of 500mg per kilo body weight for four weeks. That’s the time the experiment with mice took. A gram costs between $80 and $100 so, theoretically doses for humans would costs several hundred dollars. The French paper Libération quotes figures of half a million euro for a treatment with AICAR in a lab in Vienna. But again, there is no research whatsoever to show how much and how long you need to take it to get an effect, so figures are hard to determine. Herman Ram adds. “We do think AICAR is a bit of a hype. It’s far too expensive and there are other things on the market that do the same, and better. And again it’s dangerous because it’s never been tested on humans.” But the latter point doesn’t deter the black market in doping, with a history of untested products being used. Hype or not, AICAR is out there and apparently money isn’t deterring the ones wishing to try it. High profile riders earn lots and, secondly, with the molecular structure mapped out, it’s theoretically possible to go to a commercial lab that doesn’t have any ethical obligations against the use of doping and have it reproduced illegally. The drugs they make in bulk are of reasonable quality, and much cheaper than the originals by pharmaceutical companies Schering-Plough and GlaxoSmithKline. So, while these substances AICAR and GW1516 are on the WADA prohibited list 2012 and use of them, in any quantity, is therefore forbidden, it’s difficult to trace them because of the costs of doing so and because of the endogenous similarity to AICAR. But, according to researchers, there may be another problem looming for those who try to beat dopers and it’s called Telmisartan. Telmisartan: Telmisartan is a prescription drug for high blood pressure. It’s accepted by the U.S. Food and Drug Administration and not on the WADA list, nor is the class of drugs to which it belongs. Only specifically named substances and substances that are not approved by government regulatory bodies are on that list. Telmisartan is neither and, according to recent research by Fabian Sanchis Gomar of the University of Valencia, Spain, it has virtually the same specifics as AICAR and GW1516. It also enhances running ability in mice if they are completely untrained. With training, endurance increases, fat is burnt and recovery is faster as there is less lactic acid formation. Both WADA and the Dutch anti-doping authority know of Telmisartan but they say they are not convinced of the effects reported by the study by Sanchis-Gomar. “Recent scientific research does not seem to validate that claim,” WADA spokesmen O’Rorke insisted. Herman Ram added that there is a thin line between what is admissible and what not. “In the end everything has an effect on something. So far there hasn’t been a reason to take a closer look on Telmisartan in this respect.” Meanwhile, the substance has been found near cycling. During the same Tour de France raid in 2009 the AFLD-researchers found packages of Telmisartan. This was before research claimed similar characteristics as AICAR, and AFLD therefore couldn’t really explain its presence in a cycling-related environment. Every chemist has access to Telmisartan and because it’s not experimental anymore, it is therefore widely available. If AICAR is on WADA’s forbidden list and Telmisartan - which might have the same effects - isn’t, the latter might be a way to escape detection. More research is needed in relation to these substances, particularly as those seeking to gain unfair advantage will always try to cut corners and gain advantage over WADA and the rest of the peloton. Read more: http://www.velonation.com/News/ID/11395/Doping-AICAR-Telmisartan-and-the-need-for-vigilance.aspx#ixzz291JBGUdW
  11. Wiggo's so cool he has done a radio show with Paul Weller.
  12. AICAR - That's the name of it. I read a Shane Stokes article about that a while ago but haven't been able to remeber the name of it - reduces your body weight while maintaining your power as I recall. No test for it either... Wiggins has lost around a fifth of his body wieight in the last 18 months or so? hhhhmmmmmmm.............
  13. Brailsford was on radio 5 last night as well. What a c**t. His defence of sky signing Michael Barry was pathetic. It summed the man up perfectly.
  14. Vincenzo Nibali will have a go at some point. Nothing surer.
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